PTPN22 CC/CT with predisposing and protective HLA alleles T1DN=243 ControlsN=327 p Odds ratio 95% C.I.
  n % n %      
CT- HLA-DRB1*03:01 24 9.9 3 0.91 6.34×10-7* 10.34** 4.64-23.05
CC- HLA-DRB1*03:01 164 67.9 49 14.98 1.36 × 10-37 11.77 7.71-18.05
CT- HLA-DRB1*04:01 2 0.82 0 0 0.18* 6.78** 0.78-58.22
CC- HLA-DRB1*04:01 26 10.7 8 2.453 0.00003* 4.78** 2.05-12.41
CT- HLA-DRB1*04:03 0 0 0 0 - - -
CC- HLA-DRB1*04:03 8 3.3 29 8.86 0.0075 0.35 0.14-0.8
CT- HLA-DRB1*04:05 2 0.82 0 0 0.18* 6.78** 0.78-58.22
CC- HLA-DRB1*04:05 20 8.23 1 0.31 3.17 × 10-7* 19.96** 6.14-64.87
CT- HLA-DRB1*07:01 3 1.23 5 1.53 0.53* 0.85** 0.33-2.22
CC- HLA-DRB1*07:01 27 11.11 98 29.97 7.39 × 10-8 0.29 0.17-0.47
*Fisher’s exact test was used to calculate p values
**Haldane’s modification was used to calculate the Odds Ratio.
Table 5: Association of predisposing PTPN22 C1858T allele with predisposing HLA alleles.