Figure 1: Hedgehog signaling pathway and age-related diseases. Hedgehog signaling pathway is a morphogen, which regulates the embryonic cells during development and the multipotent cells in adults for tissue remodelling and maintenance of the function of tissues. The anti-adipogenesis and osteogenesis properties of Hedgehog signaling pathway regulate bone – adipose tissue interaction and consequently metabolic system function. Therefore, it has a direct effect in prevention of the age-related diseases.