Figure 4: Bilateral role of oxysterols (20s) in regulation of adipogenesis. While 20s via stimulation of Hedgehog signaling has a inhibitory role in the early stage of adipogenicity, it also has a stimulatory effect on adipocyte differentiation through LXR. PPARγ has the main role in this conection. LXR: Liver X Receptor, PPARγ: Peroxisome Proliferator-Activated Receptor-γ`.