Figure 1: Effect of Hp on mechanical sensitivity of diabetic mice evaluated by von Frey filaments.
Animals were evaluated before any treatment (time 0), after 7 days of streptozotocin (STZ) or saline (Sal) injection, and after treatment with hemopressin (Hp) or Sal. HP was administered once a day, orally at a dose of 2.5 mg/kg for 28 days. Data are mean ± S.E.M. 6animals per group. *** p <0.001 vs Sal+Sal and Sal+Hp group. (Two-way ANOVA followed by Bonferroni post-test).