Figure 2: Effect of Hp on thermal sensitivity of diabetic mice evaluated by the plantar test. Mice were evaluated before any treatment (time 0), after 7 days of streptozotocin (STZ) or saline (Sal) injection, and after treatment with hemopressin (Hp) or Sal. HP was administered once a day, orally at a dose of 2.5 mg/kg for 28 days. Data are mean ± S.E.M. 5animals per group. * p <0.05, ** p <0.01 and *** p <0.001 compared to group Sal+Sal and Sal+Hp. (Two-way ANOVA followed by Bonferroni post-test).