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Figure 2: Normal glucose homeostasis. This outlines the hormonal interactions that are important in regulating normal glucose homeostasis. Normal fasting glucose homeostasis involves the hormonal regulation of glucose utilization and production, as well as the filtration and reabsorption of glucose by the kidney10. Under basa conditions, glucose uptake by the tissues is matched by glucose production from the liver; this enables fine regulation of glucose at a fixed level. Gluconeogenesis in the liver helps prevent hypoglycaemia. (Reproduced with permission from Edward C. Chao, Copyright @2010, Macmilan Publishers Limited). |