Figure 4: Chronic effects of sergliflozinetabonate in Zucker fatty rats.
Sergliflozinetabonate was orally administered to Zucker fatty rats twice daily for 2 weeks. At the end of the administration period, glycated hemoglobin (A) was determined; and the oral glucose tolerance test (2 g/kg) was performed. Plasma glucose concentrations (B) were measured, and the AUC0–4 h for plasma glucose (C) was calculated from the plasma glucose concentration during the oral glucose tolerance test. Data are presented as means ± S.E.M. (n=4–5). *Pb0.05, **Pb0.01 vs. vehicle group [20].