Histone subunit Residue Modification Consequence
H2A Serine 1 Phosphorylation Mitosis, transcriptional repression
  Lysine 4 Acetylation Transcriptional activation
H2B Lysine 119 Serine 14 Ubiquitylation Phosphorylation Spermatogenesis Apoptosis
H3 Lysine 120 Lysine 4 Ubiquitylation Acetylation Meiosis Transcriptional activation
    Methylation Active euchromatin
  Lysine 9 Acetylation Transcriptional activation
    Methylation Transcriptional repression
H4 Threonine 11 Arginine 3 Phosphorylation Methylation Mitosis Transcriptional activation
  Lysine 16 Acetylation Transcriptional activation
      DNA repair
  Lysine 59 Methylation Transcriptional silencing
Adapted from Watson et al. [32], Epigenetic modification can occur through acetylaion, methylation, phosphorylation and ubiquitylation of histone subunits with different consequences to the cells through transcriptional activation or repression. The effects of such epigenetic modification of genomes may in some occasions exhibit themselves as genetic disorders. We postulate, within credence, that the above epigenetic modifications, if occurred on DR and DQ molecules, would alter the charge distributions on these molecules and consequentially derail co-operativity thereby obviating haplotypic potentials to predispose T1D: such genetically primed individuals escape this autoimmune calamity.
Table 1: Examples of epigenetic modification of molecules and their consequences.