Figure 2: Ex-4 increases NPC viability in response to diabetic-like conditions. NPCs were plated in the presence or absence of high glucose and palmitate (19 mM and 0.3 mM respectively) for 24 hours. prior to palmitate addition cells were shortly pre-incubated with Ex-4 (1 nM, 10 nM or 100 nM). (A) Intracellular ATP levels and (B) [3H] thymidine incorporation was assessed after 24 hours. Values are shown as mean ± SEM (A, n=30 B, n=8). One way ANOVA followed by Kruskal-Wallis post hoc test was used. Differences were considered significant at P<0.05. * denotes P<0.05 compared with control. # denotes P<0.05 compared with P3.