Animal models Characterization of infections in diabetic mice Infection route Cellular or molecular observation in diabetic mice with TB Reference
STZ (200mg/kg)-induced diabetes in ICR mice (T1D) with Mtb (Schacht strain) infection Reduced survival time and decreased survival incidence after Mtbinfection Intravenous injection Depression of T cell function and macrophage phagocytosis [14]
GK/ Jcl rat (T2D) with Mtb (Kurono strain) infection Larger granulomas, higher colony-forming units count in lung and spleen tissues after infection for 3 weeks Airborne route infection Less TNF-a, IL-12 secretion and NO production in alveolar macrophages stimulated with Mtb. [15]
STZ (150mg/kg)-induced diabetes in ICR mice (T1D) with Mtb(H37Rv strain) infection Increased bacterial loads in lung, liver and spleen Intravenous
Less expression level of Th1-related cytokines and iNOS in lung, liver and spleen [16]
STZ(150mg/kg)-induced diabetes in C57BL/6 mice (T1D) with Mtb (Erdman strain) infection
Akita mice (T1D) with Mtb(Erdman strain) infection
Higher bacterial lung burden and increased extent of lung inflammation Airborne route infection Increase in IFN-gand inflammatory cytokines in pooled lung lysates. Reduced antigen-specific and -nonspecific IFN-gproduction in lung T cells. [17, 18]
Diet-induced hyperglycemia in non-diabetic guinea pig (non-DM) with Mtb(H37Rv strain) infection Higher lung and extrapulmonaryMtblesion burden in sucrose-
induced hyperglycemia guinea pig
Airborne route infection Hyperglycemia-mediated AGE accumulation in lung [19]
Table 1: Comparison of the characteristics and immune dysfunction in diabetic mouse models of TB pneumonia.