Diabetes Diabetes with insulin treatment Diabetes without insulin treatment
Outcomes Estimate b(SE) P value Estimate  b(SE) P value Estimate  b(SE) P value
MMSE Scores + 0.13 (0.16) 0.39 + 0.10 (0.24) 0.69 + 0.10 (0.21) 0.65
Verbal fluency - 0.02 (0.55) 0.97 - 0.60 (0.90) 0.51 + 0.15 (0.74) 0.83
Digit span - 0.10 (0.15) 0.53 + 0.15 (0.24) 0.54 - 0.37 (0.20) 0.07
WLL delayed recall + 0.04 (0.12) 0.73 - 0.06 (0.19) 0.77 + 0.08 (0.17) 0.65
LM delayed recall + 0.09 (0.43) 0.83 - 0.35 (0.65) 0.59 + 0.52 (0.58) 0.37
Trailmaking A - 4.92 (2.80) 0.08 - 6.62 (4.20) 0.12 - 3.81 (3.81) 0.32
Trailmaking B - 2.23 (3.73) 0.55 - 4.63 (5.43) 0.4 + 0.01 (5.02) 1
Block design - 0.12 (0.40) 0.77 + 0.09 (0.66) 0.89 - 0.21 (0.52) 0.69
Plasma amylin was transformed to log10 (log10 Amylin) as a determining factor. These models were adjusted for age, gender, ethnicity, school year, ApoE4 and diabetes duration. MMSE = Mini Mental State Exam; WLL = Word learning list; LM = Logical memory
Table 6: Effects of plasma amylin on cognitive tests in multivariate regression analyses in the presence of diabetes.