MMSE Word recall DSST Stroop test
Immediate Delayed
HAI          
Univariate analysis -0.284* -0.470**** -0.470**** -0.311* 0.278*
Multivariate analysis          
Model 1 -0.229(0.409)# -0.367(0.185)*** -0.440(0.298)*** -0.210(1.498) 0.300(1.375)*
Model 2 -0.065(0.544) -0.406(0.246)** -0.503(0.390)*** -0.189(1.689) 0.445(1.692)**
Model 3 -0.116(0.567) -0.459(0.250)** -0.571(0.399)*** -0.214(1.708) 0.486(1.766)**
WBAR          
Univariate analysis -0.263* -0.494**** -0.463**** -0.492**** 0.361***
Multivariate analysis          
Model 1 -0.191(0.149) -0.396(0.067)*** -0.459(0.108)*** -0.442(0.505)*** 0.453(0.482)***
Model 2 -0.057(0.177) -0.366(0.081)* -0.453(0.128)*** -0.332(0.526)* 0.372(0.560)*
Model 3 -0.071(0.197) -0.350(0.090)* -0.522(0.141)** -0.270(0.582)# 0.485(0.612)**
In the multivariate analysis cognitive function domains were used as dependent variables. Values are correlation coefficients in the univariate analysis and standardized β coefficient (SE) in the multivariate analysis. Model 1 is adjusted for age, sex, and years of education. Model 2 is adjusted for duration of diabetes, body mass index, current smoking, treatment modality, diastolic blood pressure, log triglycerides, uric acid, sICAM-1, log hs-CRP, log TNF-α, log IL-6, albuminuria, and eGFRcys<60ml/min/m2 in addition to the factors in Model 1. Model 3 is adjusted for SBI, PWMLs and SWMLs in addition to the factors in Model 2. #p<0.1, *p<0.01, **p<0.01, ***p<0.005, ****p<0.001
Table 3: Associations between hippocampus atrophy index (HAI) and whole brain atrophy rate (WBAR) and cognitive function domains.