Figure 2: Weight loss in RYGB mice (Cohort 3). RYGB surgery was performed in DIO mice at 14 wks on HFD with body weight around 50g, and sham operation was performed in the control mice. After surgery, the mice were fed chow diet (11% fat wt/wt, 5015 LabDiet) to mimic the dietary condition in patients. A. Body weight change. B. Percentage change in body weight. C. Body composition. The composition test was conducted at 7 wks after surgery. D. Food intake at 6 wks after surgery. The data are presented as mean ± SE (n=7-8). *P< 0.01, **p< 0.001 RYGB vs. sham by student’s t test.