Figure 1: Proposed actions of GA in ameliorating MetS via modulation of GC in different tissues through inhibition of 11beta;-HSD1. [11β-HSD: 11beta;-hydroxysteroid dehydrogenase; CVD: cardiovascular disease; G6Pase: glucose-6-phosphatase; GA: Glycyrrhizic acid; GC: glucocorticoids; H6PDH: hexose-6-phopshate dehydrogenase; IR: insulin resistance; PEPCK: phosphoenolpyruvate carboxykinase; MetS: metabolic syndrome; T2DM: Type 2 diabetes mellitus].