Figure 2: Schematic representation of substrate metabolism in myocytes. Hyperglycemic milieu causes elevated CD36 recruitment on the membrane, increasing fattyacid (FFA) uptake. Impaired regulation due to increased FFA uptake involves increased malonyl-CoA, inhibiting FA oxidation, and increased ROS formation. This further influences triglyceride (TG) accumulation and glycogen formation due to decreased glucose oxidation. Abbreviations: MCD – Malonyl CoA decarboxylase, ACC – Acetyl-CoA, CPT1 – Carnitine palmitoyl transferase 1, MCT – Mono-carboxylase carrier.