Figure 5: Schematic drawing depicting the effect of hyperglycemia on myofibrillar contraction. a. relaxed myofibril b. contracted myofibril c. sarcoplasmic reticulum d. nucleus. Calcium level is increased in the cytosol via ryanodine receptor (RyR) on SR membrane and L type receptors present on sarcomere mediating myofibrillar contraction. This condition is reverted back by reuptake of calcium into SR via SERCA pump. Under hyperglycemic ambience glycated SERCA pump prevents the reuptake of calcium, thereby increasing the contraction of myocytes causing ventricular dysfunctioning.