| Histone modification |
| Source |
PTM |
Drugs |
Role of drugs |
Promoter |
| H3K9/14 |
↑Acetylation |
Losartan |
Inhibits HAT |
RAGE and PAI-1 |
H3K4
H3K9/14 |
↓Methylation
↓Acetylation |
Esculetin(6, 7-dihydroxycoumarin) |
Radical scavenger Anti-proliferative
Anti-fibrotic |
TGF-β, PPAR-γ |
| H3K36 |
↑Methylation |
Losartan |
Inhibits methyl transferase |
RAGE and PAI-1 |
| H3K9/14 |
↑Acetylation |
Atorvastatin |
Promotes HAT |
ACE2 |
| H3K4/14 |
↓Acetylation |
Curcumin analogue C66 |
p300/CBP-mediated deacetylation |
- |
| H2AK119 and H2BK120 |
↑ubiquitination |
Esculetin |
Reversal of post translational modifications |
AT1R, AT2R and ACE2 |
| H3K27 and H3K9 |
↓Trimethylation |
- |
- |
ANP, BNP |
| DNA methylation |
| Source |
PTM |
Drugs |
Role of drugs |
Promoter |
| CpG islands |
Demethylation |
- |
- |
Keap1 |
| CpG islands |
↑Methylation |
SPV106 |
HAT activator |
Cell cycle and DNA repair |
| Chromatin remodeling |
| Source |
PTM |
Effect of PTM |
Promoter |
| Histone deacetylation |
↑Brg1, ↑Baf180 and ↑Baf60c |
Diabetic cardiac hypertrophy |
Fetal gene |
| Ser727 and Try705 |
Phosphorylation, ↓Brg1 |
diastolic dysfunction |
STAT3 |
