Figure 2B: Molecular model of the intrarenal RAS activation and Ang 1-7 action in diabetes. (B) Antagonistic effect of exogenous Ang 1-7 on intrarenal RAS activation and kidney injury in diabetes. Exogenous Ang 1-7 improves ACE2 levels which effectively degrades Ang II and inhibits its downstream signalling. Ang 1-7 also limits Ang II formation by inhibiting Nrf2-stimulation of Agt gene expression and attenuating the ACE2/Ang 1-7/MasR axis, which eventually leads to a healthy kidney condition. (Ang II is shown as yellow circles and Ang 1-7 is shown as red circles) (modified from