Figure 3: Mouse strain affects the magnitude of STZ-induced T1D reduction in bone volume fraction. Trabecular bone volume fraction (BVF) was determined in the region of the distal femur. 129/Sv lost significantly more BVF compared to Balb/c and C57BL/6 diabetic mice. Percent BVF was calculated using μCT imaging technique and displayed relative to individual strain’s control. Bars represent the average value ± SE (n ≥ 8-10 per group); * denotes p<0.05.