**Table 3: Compound 1 increases metabolic rate and energy expenditure in DIO mice**
Oxygen uptake (VO_{2}), Carbon dioxide output (VCO_{2}), respiratory exchange ratio (RER) and heat generation were measured by indirect calorimetry after 4 weeks of compound treatment in groups of 3 DIO mice from each group. Values were normalized to lean body mass (LBM), and represent means ± SD. Maximal aerobic capacity was calculated as milliliter (ml) O_{2}/minute (min)/per gram (g) LBM. Statistical
significance was calculated by using the two sample, paired t test. P values shown are for compound 1 versus vehicle group. *P=0.04 for heat production and P=0.02 for maximal aerobic capacity. |