Figure 1: Blood glucose and body weight in wild-type and Akita/+ male mice. Akita/+ male mice have spontaneous high glucose starting from 1 month. Body weight (A) and blood glucose levels (B) were monitored for up to 6 months in wild-type (WT), Akita/+ and Akita/+; TSP1 -/- male mice (n=10). Note Akita/+ and Akita/+; TSP1 -/- mice developed sustained hyperglycemia.