Figure 1: Structure of adipose tissue. Adipose tissue (AT) is composed of a collagenous background together with different cell types, which are seeded in this connective tissue. Adipocytes are the major constitute cells in AT and the main site for the storage and release of cytokines and chemokines. Metabolic disorders appeared to stimulate adipocytes to prime inflammation and, in turn, resident or regulated macrophages converted to activated macrophages and then exacerbated by these activated Adipose tissue macrophages (ATM). Preadipocytes are the next most abundant cells and the linker between adipocytes (metabolic cells) and macrophages (immune cells). Other cells of the adipose tissue are fibroblasts, mesenchymal stem cells and endothelial cells that each one has an important role in different pathways including the metabolic, coagulation and inflammatory systems.