Figure 4: Role of insulin in three main peripheral tissues (Liver, Skeletal muscle and Adipose tissue). In insulin sensitive state of body, a functional adipose tissue absorb circulatory and peripheral FFAs and storage them via lipogenesis in its lipid droplets. This event relief suppression effect of lipid on insulin pathway and enhances glucose absorption by cells. Consumption of glucose by cells has a negative effect on intracellular lipolysis. Existence of enough intracellular glucose in peripheral tissues, inhibit liver-gluconeogenesis to overcome the lack of peripheral glucose. In insulin resistance state, due to chronic inflammation of adipose tissue, lipolysis and release of FFA from adipose tissue and sedimentation in peripheral tissues decrease the function of the insulin pathway. The final consequence of this process is dyslipidemia, hyperglycemia and liver-gluconeogenesis. FFA: Free Fatty Acid; LD: Lipid Droplet; TG: Triglyceride