Criteria GK T2DN
Early increase in GFR (hyperfiltration) + + + +
>10-fold increase in albuminuria + + + +
Mesangial matrix expansion + + + +
Thickening of glomerular basement membrane + + + +
Renal interstitial fibrosis + + + +
Arteriolar hyalinosis NO YES
Nodular glomerular lesions NO YES
50% decline in renal function NO YES
These criteria were set forth by the AMDCC for a rodent model of diabetic nephropathy
+indicates the severity within the individual criteria as compared to nondiabetic rat strains
Table 1: Criteria for diabetic nephropathy in GK and T2DN rats.