Figure 5: The effect of linagliptin on FN transcription is not TSP-1 mediated Linagliptin reduced high glucose induced FN mRNA transcription. Recombinant TSP-1 did not have any additional effects when added to 30 mM glucose. In the presence of excess recombinant TSP-1, linagliptin was still able to suppress FN. N=5, *p<0.05 vs. ctrl, † p<0.05 vs. 30 mM Glu.