Figure 6: The effect of DPP4 inhibition on AP-1 binding DPP4 inhibition with linagliptin (30 nM) reduced high glucose induced AP-1 binding. HK2 cells were treated with high glucose (30 mM) and linagliptin (30 nM) for 72h. Nuclear extract was collected and AP-1was quantitated using EMSA. N=3, *p<0.05 vs. ctrl, † p<0.05 vs. 30 mM Glu.