**MOTIVATING MODEL** |
**ANALYSIS GOAL** |

**Large change** |
**Reliably measured change** |

Independence/Normality of Genes |
Difference in Expression (F) |
Tâ€“statistic (T) |

Exchangeability of Genes |
Significance Analysis of Microarray (SAM) |

Complete Conjugacy |
Signal (CC.F) |
Standardized Signal (CC.T) |

Tail probability (CC.TP) |
Bayes factor (CC.BF) |

Independence of Abundance and Noise |
Signal (CI.F) |
Standardized Signal (CI.T) |

Tail probability (CI.TP) |
Bayes factor (CI.BF) |

Independence of Signal and Noise |
Signal (IC.F) |
Standardized Signal (IC.T) |

Tail probability (IC.TP) |
Bayes factor (IC.BF) |

Independence |
Signal (II.F) |
Standardized Signal (II.T) |

Tail probability (II.TP) |
Bayes factor (II.BF) |