Threshold value, x No. studies with this threshold Sensitivity Specificity
Summary estimate 95% CI Summary estimate 95% CI
lower   upper lower   upper
0.13 1 0.941 0.896 0.967 0.698 0.544 0.818
0.14 2 0.936 0.889 0.963 0.720 0.572 0.832
0.15 5 0.930 0.882 0.959 0.740 0.597 0.845
0.16 3 0.924 0.875 0.955 0.756 0.618 0.856
0.17 3 0.919 0.867 0.951 0.770 0.637 0.865
0.18 3 0.913 0.859 0.948 0.782 0.653 0.873
0.19 4 0.907 0.851 0.944 0.793 0.666 0.880
0.2 6 0.902 0.843 0.940 0.801 0.678 0.885
0.21 3 0.896 0.835 0.937 0.809 0.688 0.890
0.22 1 0.891 0.827 0.933 0.815 0.697 0.894
0.23 1 0.886 0.820 0.930 0.820 0.704 0.897
0.24 2 0.881 0.812 0.926 0.824 0.709 0.900
0.25 2 0.876 0.805 0.923 0.828 0.714 0.902
0.28 2 0.862 0.786 0.914 0.834 0.724 0.907
0.3 4 0.854 0.774 0.909 0.837 0.727 0.908
0.31 1 0.850 0.768 0.906 0.838 0.729 0.909
0.32 1 0.846 0.763 0.904 0.839 0.730 0.909
0.35 1 0.835 0.748 0.897 0.841 0.733 0.910
0.39 2 0.822 0.729 0.888 0.846 0.740 0.914
0.4 2 0.819 0.724 0.886 0.848 0.743 0.915
0.45 1 0.800 0.699 0.874 0.867 0.770 0.927
0.49 1 0.781 0.674 0.860 0.892 0.806 0.943
0.5 2 0.775 0.665 0.857 0.900 0.816 0.948
Table 4: Summary results from REML estimation of meta-analysis model (9) (cubic relationship).