METH Ref. Grade (Well) Stage (Localized) Histology ER Status (ER+) PR Status (PR+) Moderate Poor Distant Lobular Other ER− PR− %missing 23.2 21.2 0 30 33.6  θ(0) CMLE EST 1.312 −0.160 −0.033 0.703 −0.652 0.379 −0.126 −0.879   SE 0.357 0.386 0.415 0.354 0.443 0.523 0.42 0.339   p-value <0.001 0.679 0.937 0.047 0.142 0.469 0.764 0.009 MLE EST 0.961 0.04 0.268 0.795 −0.666 0.404 0.233 −0.693   SE 0.305 0.332 0.357 0.263 0.307 0.349 0.376 0.308   p-value 0.002 0.904 0.452 0.003 0.03 0.246 0.535 0.025 PCL EST 1.066 0.025 0.128 0.81 −0.685 0.368 0.883 −1.222   SE 0.273 0.317 0.346 0.261 0.303 0.351 0.439 0.359   p-value <0.001 0.937 0.711 0.002 0.024 0.294 0.045 0.001

Table 5: Results of the CPS-II Nutrition Cohort data analysis with five disease traits and weight gain from age 18 to 1992 as the predictor. Here EST, SE, METH, ER and PR stand for estimate, standard error, method, estrogen receptor and progesterone receptor, respectively.