Risk/ protective variants Number of variants Relative risk MAF-Cutoff NET SKAT REP C-ALPHA MB CMC
15/0 100 3.0 0.01 24.4 18.2 28.8 16.3 16.6 13.4
10/0 100 3.0 0.01 16.6 14.3 18.0 11.9 10.4 7.5
15/10 100 3.0 0.01 21.7 22.3 20.1 18.3 10.5 7.2
10/10 100 3.0 0.01 14.5 19.1 13.1 16.0 5.0 5.5
15/0 100 2.0 0.01 12.8 8.6 14.4 7.0 7.7 7.1
10/0 100 2.0 0.01 9.8 7.6 9.3 6.9 5.4 4.9
15/10 100 2.0 0.01 9.6 9.2 9.0 6.9 5.7 4.9
10/10 100 2.0 0.01 5.4 8.4 7.2 7.8 3.4 5.2
15/0 500 3.0 0.01 16.9 12.0 15.7 9.7 8.6 3.7
10/0 500 3.0 0.01 10.4 11.1 11.2 8.8 6.4 4.5
15/10 500 3.0 0.01 13.0 13.3 11.0 11.2 6.7 3.2
10/10 500 3.0 0.01 11.6 9.3 7.5 7.4 5.0 3.5
15/0 500 2.0 0.01 8.6 6.9 10.7 5.1 6.1 3.1
10/0 500 2.0 0.01 8.5 7.3 7.5 6.2 5.2 3.2
15/10 500 2.0 0.01 8.5 7.3 6.9 5.2 5.8 3.8
10/10 500 2.0 0.01 6.6 8.6 5.5 6.5 3.4 2.9
15/0 100 3.0 0.05 47.1 54.4 59.7 55.4 39.2 12.3
10/0 100 3.0 0.05 32.8 35.3 38.3 38.4 21.3 8.2
15/10 100 3.0 0.05 37.2 68.6 46.4 66.3 19.9 7.3
10/10 100 3.0 0.05 21.1 49.8 25.1 47.9 9.8 3.9
15/0 100 2.0 0.05 25.0 18.5 25.4 17.8 15.0 5.6
10/0 100 2.0 0.05 15.5 12.6 17.4 9.6 12.4 4.2
15/10 100 2.0 0.05 15.7 24.1 17.3 24.4 8.2 3.8
10/10 100 2.0 0.05 9.8 21.1 11.0 18.0 6.5 4,50
15/0 500 3.0 0.05 31.8 39.4 38.0 34.6 18.3 NA
10/0 500 3.0 0.05 19.2 25.8 23.3 20.3 11.0 NA
15/10 500 3.0 0.05 23.6 52.5 32.5 43.3 12.7 NA
10/10 500 3.0 0.05 15.4 38.7 18.6 30.5 8.2 NA
Note: All shown power estimates are based on 1000 replicates and 1000 permutations.
Table 2: Power estimates of the outlined approaches for the random scenario (100/500 variants, upper MAF-threshold 0.01/0.05, 500/500 cases/controls).