Table 2

Risk/ protective variants	Number of variants	Relative risk	MAF-Cutoff	NET	SKAT	REP	C-ALPHA	MB	CMC
15/0	100	3.0	0.01	24.4	18.2	28.8	16.3	16.6	13.4
10/0	100	3.0	0.01	16.6	14.3	18.0	11.9	10.4	7.5
15/10	100	3.0	0.01	21.7	22.3	20.1	18.3	10.5	7.2
10/10	100	3.0	0.01	14.5	19.1	13.1	16.0	5.0	5.5
15/0	100	2.0	0.01	12.8	8.6	14.4	7.0	7.7	7.1
10/0	100	2.0	0.01	9.8	7.6	9.3	6.9	5.4	4.9
15/10	100	2.0	0.01	9.6	9.2	9.0	6.9	5.7	4.9
10/10	100	2.0	0.01	5.4	8.4	7.2	7.8	3.4	5.2
15/0	500	3.0	0.01	16.9	12.0	15.7	9.7	8.6	3.7
10/0	500	3.0	0.01	10.4	11.1	11.2	8.8	6.4	4.5
15/10	500	3.0	0.01	13.0	13.3	11.0	11.2	6.7	3.2
10/10	500	3.0	0.01	11.6	9.3	7.5	7.4	5.0	3.5
15/0	500	2.0	0.01	8.6	6.9	10.7	5.1	6.1	3.1
10/0	500	2.0	0.01	8.5	7.3	7.5	6.2	5.2	3.2
15/10	500	2.0	0.01	8.5	7.3	6.9	5.2	5.8	3.8
10/10	500	2.0	0.01	6.6	8.6	5.5	6.5	3.4	2.9
15/0	100	3.0	0.05	47.1	54.4	59.7	55.4	39.2	12.3
10/0	100	3.0	0.05	32.8	35.3	38.3	38.4	21.3	8.2
15/10	100	3.0	0.05	37.2	68.6	46.4	66.3	19.9	7.3
10/10	100	3.0	0.05	21.1	49.8	25.1	47.9	9.8	3.9
15/0	100	2.0	0.05	25.0	18.5	25.4	17.8	15.0	5.6
10/0	100	2.0	0.05	15.5	12.6	17.4	9.6	12.4	4.2
15/10	100	2.0	0.05	15.7	24.1	17.3	24.4	8.2	3.8
10/10	100	2.0	0.05	9.8	21.1	11.0	18.0	6.5	4,50
15/0	500	3.0	0.05	31.8	39.4	38.0	34.6	18.3	NA
10/0	500	3.0	0.05	19.2	25.8	23.3	20.3	11.0	NA
15/10	500	3.0	0.05	23.6	52.5	32.5	43.3	12.7	NA
10/10	500	3.0	0.05	15.4	38.7	18.6	30.5	8.2	NA

Note: All shown power estimates are based on 1000 replicates and 1000 permutations.

Table 2: Power estimates of the outlined approaches for the random scenario (100/500 variants, upper MAF-threshold 0.01/0.05, 500/500 cases/controls).