Effects Description Mean Response Structure*
(1.1) No group difference image
(1.2) Difference between groups constant across 24-hour sequence image
(1.3) Group-specific mean response functions have different quadratic trends image
(1.4) Group-specific mean response functions smoothed differently using distinct vectors of coefficients for OSA and Control profiles image
(1.5) Separate smoothing and distinct smoothing parameters for OSA and Control profiles Same as structure (1.4) but differing variances for smoothing coefficients: imageand image
The term OSAi indicates whether subject belongs to the OSA or Control group (1=OSA, 0=Control); similarly, CTRi indicates group membership for spline-based differences (1=Control, 0=otherwise).
Table 1: Class of semiparametric mixed models to evaluate group-specific differences in twenty-four hour diastolic blood pressure.