**Figure 9:** **Simulation of genes with fixed T-statistic but varying fold
changes and standard deviations:** a) Significance is plotted in function of
the standard deviation for the T-test (upper left) where no differentiation is
found. b) The upper right plot, displays the results for limma where penalization
is taken place for low variance genes. c) But most penalization can be found
for the balanced test (lower left). Here the Rj values are log10 transformed since
all Rj ≥ 1.d) The lower right plot graphs fold changes in function of variance. |