Effect   Separate model (PR&RR) Joint model (PR&RR)
Estimate (SE) P-value (1-α)100% CI Estimate (SE) P-value (1-α)100% CI
For PR            
Inter(β10) 107.04(4.415) <.0001 (98.37,115.71) 108.58(4.384) <.0001 (99.97,117.1)
Time(β11) -3.15(0.123) <.0001 (-3.39,-2.904) -3.16(0.122) <.0001 (-3.4,-2.923)
Age(β12) -0.41(0.053) <.0001 (-0.513,-0.304) -0.43(0.053) <.0001 (-0.53,-0.32)
Sex(β13) 4.804(1.422) 0.0008 (2.007,7.602) 4.528(1.335) 0.0008 (1.902,7.153)

NYHA  Class  

II(β14) 2.743(1.913) 0.1528 (-1.024,6.51) 3.187(1.908) 0.0961 (-0.57,6.944)
III(β15) 5.167(2.423) 0.0339 (0.396,9.938) 5.896(2.415) 0.0153 (1.14,10.652)
IV(β16) 15.153(2.801) <.0001 (9.637,20.669) 16.055(2.794) <.0001 (10.55,21.56)
L(β17) -0.31(0.016) <.0001 (-0.339,-0.275) -0.30(0.016) <.0001 (-0.33,-0.26)
T*L(β18) 0.009(0.0008) <.0001 (0.0075,0.011) 0.009(0.0008) <.0001 (0.007,0.01)
W(β19) 0.538(0.033) <.0001 (0.474,0.603) 0.521(0.032) <.0001 (0.458,0.584)
T*W(β110) 0.016(0.0014) <.0001 (0.013, 0.019) 0.016(0.0014) <.0001 (0.013,0.019)
Sigma1(σ1) 31.53(0.58) <.0001 (30.423,32.699) 31.579(0.582) <.0001 (30.47,32.751)
image 141.27(13.14) <.0001 (118.68,171.03) 140.62(13.16) <.0001 (118.02,170.44)
image -2.207(0.395) <.0001 (-2.982,-1.432) -2.078(0.388) <.0001 -2.84(-1.317)
image 0.182(0.02) <.0001 (0.148,0.229) 0.176(0.019) <.0001 (0.143,0.221)
For RR            
Inter(image) 37.08(1.785) <.0001 (33.57,40.59) 36.57(1.78) <.0001 (33.06,40.07)
Time(image) -0.787(0.034) <.0001 (-0.853,-0.72) -0.779(0.034) <.0001 (-0.845,-0.713)
Age(image) -0.258(0.025) <.0001 (-0.308,-0.209) -0.256(0.025) <.0001 (-0.305,-0.207)
Sex(image) 1.605(0.578) 0.0057 (0.47,2.739) 1.734(0.569) 0.0024 (0.617,2.851)
NYHA II(image) 2.056 (0.898) 0.0227 (0.289,3.823) 1.99(0.895) 0.0270 (0.228,3.753)
III(β25) 4.022 (1.136) 0.0005 (1.786,6.258) 3.936(1.133) 0.0006 (1.706,6.166)
IV(β26) 8.937(1.314) <.0001 (6.349,11.525) 8.83(1.311) <.0001 (6.249,11.412)
L(β27) -0.075(0.004) <.0001 (-0.082,-0.067) -0.075(0.004) <.0001 (-0.082,-0.067)
T*L(β28) 0.002(0.0002) <.0001 (0.0019,0.0026) 0.002(0.00019) <.0001 (0.002,0.0026)
W (β29) 0.054 (0.0081) <.0001 (0.038,0.07) 0.059 (0.008) <.0001 (0.043,0.075)
T*W(β210) 0.003 (0.0004) <.0001 (0.002,0.0034) 0.003(0.00035) <.0001 (0.002,0.0033)
Sigma2σ2 1.654 (0.031) <.0001 (1.595,1.715) 1.657(0.031) <.0001 (1.598,1.719)
image 31.63 (2.915) <.0001 (26.61,38.22) 31.696 (2.93) <.0001 (26.658,38.319)
image -0.604(0.112) <.0001 (-0.82,-0.39) -0.6 (0.11) <.0001 (-0.82,-0.38)
image 0.066 (0.007) <.0001 (0.054,0.083) 0.064(0.0068) <.0001 (0.052,0.079)
Common parameters image   - 32.626(4.763) <.0001 (23.292,41.96)
image     0.23(0.22) 0.2939 (-0.2,0.66)
image     -0.037(0.172) 0.8283 (-0.375,0.3)
image     0.075(0.004) <.0001 (0.012, 0.138)
   Rho (ρ)     0.7054(0.032) <.0001 (0.642,0.769)
NB: T=Time, W=Weight, L= LVEF, inter=intercept
Table 6: Results for separate and joint or shared model.