Variable Category Male (n=402) Female (n=1293) Mean (SD) % Median Mean (SD) % Median Age (years) - 39.4 (14.3) - 40.3 42.9 (12.1) - 44.0 BMI Overall 27.4 (4.5) - 26.8 26.2 (5.1) - 25.2 Normal/underweight 22.9 (1.6) 32.8 - 22.4 (1.8) 48.8 - Overweight/obese 29.6 (3.8) 67.2 - 29.9 (4.6) 51.2 - PTF - 29.5 (9.8) - 30.7 38.4 (8.9) - 39.6 Smoking status Non-smoking - 87.8 - - 89.4 - Smoking - 12.2 - - 10.6 - Alcohol consumption No alcohol - 15.9 - - 20.9 - Low - 60.2 - - 67.1 - Moderate - 20.2 - - 10.7 - High - 3.7 - - 1.3 - Physical activity category Low - 20.9 - - 22.1 - Moderate - 61.2 - - 67.7 - High - 17.9 - - 10.2 - Physical activity score - 6.4 (1.4) - 6.5 6.2 (1.3) - 6.0

Table 1: Summary data of unrelated individuals from the CODING study used in this analysis.