Model                    Naive Survival Model                Corrected Survival Model Covariate Coefficient     SE   P-val       95% CI Coefficient    SE   P-val       95% CI    LL4    UL5     LL     UL IL101 0.267 0.084 0.001 0.103 0.431 0.232 0.065 0.000 0.105 0.359 Age2 0.593 0.098 0.000 0.401 0.786 0.602 0.099 0.000 0.409 0.796 Gender -0.431 0.224 0.054 -0.870 0.008 -0.436 0.224 0.051 -0.874 0.003 Steroid 0.393 0.222 0.076 -0.042 0.828 0.351 0.223 0.115 -0.086 0.788 D-dimer3 0.281 0.093 0.003 0.099 0.463 0.276 0.093 0.003 0.094 0.458 1Log of IL10 where censored values are replaced by the LOD=5; 2Age is divided by 10 for better interpretation; 3Log of D-dimer; 4LL denotes lower limit of the 95% confidence interval; 5UL denotes the upper limit of the 95% confidence interval.

Table 3: GenIMS study results of a parametric survival model when IL10 is subject to limit of detection.