Variable Difference in the Z-score 95% Confidence Interval Unadjusted
p-value
CM – CC at each time point
CM – CC: baseline -1.14 (-1.51, -0.77) < 0.0001
CM – CC: 3 months -0.40 (-0.77, -0.02) 0.04
CM – CC: 6 months -0.55 (-0.92, -0.17) 0.005
CM – CC: 2 years -0.55 (-0.94, -0.17) 0.005
UM – CC at each time point
UM – CC: baseline 0.21 (-0.13, 0.56) 0.22
UM – CC: 3 months 0.26 (-0.09, 0.60) 0.15
UM – CC: 6 months 0.05 (-0.30, 0.40) 0.77
UM – CC: 2 years 0.02 (-0.33, 0.37) 0.91
CM trend over time
CM: 3 months – baseline 0.76 (0.54, 0.98) < 0.0001
CM: 6 months – 3 months -0.15 (-0.38, 0.07) 0.17
CM: 2 years – 6 months -0.02 (-0.24, 0.21) 0.89
Table 2: Estimates of the difference in neurocognitive Z-scores over time in children with cerebral malaria (CM), uncomplicated malaria (UM) and community children (CC) from the linear mixed effects model.