| Dendrimer |
Commercially Available |
Applications |
| PAMAM |
STARBURST® dendrimers (Sigma Aldrich) |
• In vitro transfection of liver (HepG2) and colon (CT26) cells |
| • In vivo gene delivery |
| • In vitro transfection into mesenchymal stem cells |
| • Formation of stable PAMAM-transferrin conjugate to form stable dendriplexes with plasmid DNA and improved gene delivery to HeLa, HepG2 and CT26 cell lines. |
| • Delivery of sticky siRNAin vivo and in vitro to prostate cancer model using triethanolamine (TEA)-core PAMAM dendrimer of generation five. |
| PPI |
Astramol (Dutch State Mines (DSM) Netherlands and Aldrich Chemical Company) |
• siRNA delivery |
| • Successful gene expression in liver rather than other organs |
| • Accumulation in tumor tissue and induction of tumor- specific gene expression |
| • PPI-collagen conjugates used as a scaffold for corneal tissue engineering. |
| • Generation 4 and 5 PPI dendrimers to knockdown mRNA in A549 human lung cancer cells |
| PEI |
|
• Gold standard for plasmid DNA delivery |
| • Delivery of short hairpin RNA (shRNA) to retinal ganglion cells |
| • Pulmonary gene delivery in vivo |
| Glycodendrimers |
|
• In vivo transfection of mannose-conjugated α-cyclodextrins in mouse kidney |
| PLL |
|
• In vivo transfection of generation 6 PLL-plasmid injected intravenously in mice |
| • In vitrotransfection in different cells |
| • Effective knockdown of GAPDH in rat hepatoma (H4IIEC3) cells with low cytotoxicity. |
| Carbosilane |
|
• 2G-NN16 and 2G-03NN24 carbosilanedendrimers in gene therapy of HIV infection |
