Strategy Achievements Problems References
Growth factor based approaches Proven to be effective
Control vascularization
Very slow vascularization
Prolong storage of these growth factors
[40,44,63]
Synthetic oxygen carrier Blood substitute
Increased tissue oxygenation
Biologically inert
Molecules are seize in the reticuloendothelial system
[10,35,38,44,64]
Scaffolds for oxygen release Versatile strategy
Used for multiple cells
Limited results to be expected
Cell seeding problems
[11,39]
Oxygen release micro-system Versatile applications
Used for multiple cells
Only oxygen and water were produced as by products
Size (micro) [12,13]
Table 1: Comparison of different strategies used for generating oxygen.