| Scaffold Material |
Biomimetic Properties |
Examples |
Tissue Engineering Applications |
| Collagen |
- Natural polymer, found in skin, cartilage, and bone
- Integrin binding sites for enhanced cell adhesion
- Biodegradable and non-toxic |
- Excellagen®
- Hydrogels
- Microribbons |
- Cross-linkable and injectable for wound repair
- Promote reepithelialization and granulation tissue growth in diabetic ulcers
- Tunable for tissue-specific cues |
| Hyaluronic Acid |
- GAG found in synovial fluid and connective tissue ECM
- Excellent biocompatibility and biodegradability |
- Hydrogels
- HYALONECT® |
- Inherently reduces inflammatory response and promotes angiogenesis in tissues
- HA-based mesh promotes bone and periosteum regeneration |
| Fibrin |
- Glycoprotein responsible for hemostasis during injury
- Natural provisional ECM to sequester growth factors and cells |
- QuikClot®
- Fibrant Sealant Dressing
- Hydrogels |
- Made from autologous blood to prevent immunoresponse
- Minimally-invasive delivery method for MSCs into bone defects |
| Chitosan |
- Naturally occurring polysaccharide with cell-adhesive qualities
- Structural resemblance to many crucial GAGs in cartilage |
- Hydrogels
- Antibiotic-loaded bar |
- High porosity, 3D structure, and GAG content ideal for chondrogenesis
- Intrinsic antibiotic qualities to prevent infection of tissue |
| Decellularized ECM |
- Contains crucial proteins, GAGs, and structural components
- Biocompatible and biodegradable |
- Graftjackt® |
- in vitro engineering of scaffolds for autologous applications
- Improve healing of chronic diabetic foot ulcers |
