Canonical Pathwaysa p-valueb
IL-3 Signaling 1.98E00
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 1.86E00
p53 (tumor protein 53 ) Signaling 1.82E00
Role of NFAT (nuclear factor of activated T cells) in Regulation of the Immune Response 1.8E00
T Cell Receptor Signaling 1.73E00
CD28 Signaling in T Helper Cells 1.52E00
EGF (Epidermal growth factor )Signaling 1.42E00
IL-2 Signaling 1.29E00
GM-CSF (Granulocyte-macrophage colony-stimulating factor ) Signaling 1.21E00
CD40 Signaling 1.19E00
Macropinocytosis Signaling 1.15E00
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 1.04E00
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4)  Signaling in Cytotoxic T Lymphocytes 1.03E00
SAPK/JNK  (stress-activated protein kinase/c-Jun NH2-terminal kinase ) Signaling 1.02E00
IL-12 Signaling and Production in Macrophages 8.96E-01
IGF-1 (insulin-like growth factors ) Signaling 8.78E-01
TNFR2 (Tumor necrosis facrorrecptor 2) Signaling 7.65E-01
IL-9 Signaling 7.32E-01
MIF (Macrophage migration inhibition factor ) Regulation of Innate Immunity 7.02E-01
B Cell Receptor Signaling 6.89E-01
B Cell Activating Factor Signaling 6.62E-01
IL-17A Signaling in Fibroblasts 6.62E-01
Clathrin-mediated Endocytosis Signaling 6.3E-01
Endothelin-1 Signaling 6.24E-01
TNFR1(Tumor necrosis facrorrecptor 1)  Signaling 6.14E-01
CXCR4 (C-X-C chemokine receptor type 4) Signaling 6.13E-01
CD27 Signaling in Lymphocytes 6.03E-01
Toll-like Receptor Signaling 5.82E-01
LPS/IL-1 Mediated Inhibition of RXR (Retinoid X receptor beta (RXR-beta ) Function 5.72E-01
Acute Phase Response Signaling 5.53E-01
IL-8 Signaling 5.43E-01
Leukocyte Extravasation Signaling 5.39E-01
Molecular Mechanisms of Cancer 5.37E-01
Role of JAK1 (Janus kinase 1)and JAK3 (Janus kinase 3) in γc Cytokine Signaling 5.27E-01
IL-4 Signaling 5.19E-01
IL-17A Signaling in Airway Cells 5.11E-01
JAK/Stat (Janus kinase/ Signal Transducer and Activator of Transcription) Signaling 4.95E-01
Chemokine Signaling 4.95E-01
IL-10 Signaling 4.87E-01
IL-15 Signaling 4.87E-01
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 4.66E-01
CCR5 (C-C chemokine receptor type 5 )Signaling in Macrophages 4.53E-01
IL-17 Signaling 4.46E-01
TGF-β (Transforming growth factor beta ) Signaling 4.22E-01
Natural Killer Cell Signaling 3.64E-01
IL-1 Signaling 3.55E-01
VEGF (Vascular endothelial growth factor ) Signaling 3.5E-01
Virus Entry via Endocytic Pathways 3.46E-01
IL-6 Signaling 3.46E-01
Fc Epsilon RI Signaling 3.37E-01
CCR3 C-C chemokine receptor type 3 )Signaling in Eosinophils 3.21E-01
Cdc42 (Cell division control protein 42) Signaling 2.99E-01
Dendritic Cell Maturation 2.6E-01
NF-κB ((nuclear factor kappa-light-chain-enhancer of activated B cells) Signaling 2E-01
aFunctional annotation analysis of the differentially expressed genes (DEGs) with the IPA (Ingenuity Pathway Analysis, http://www.ingenuity.com) tools. The IPA tool defines the most significant biological functions through association with the largest number of DEGs correlated to these functions. Canonical pathways are known classic routes and well-established of biological functions evidenced by validated genes.
bP value determined from the average log2 ratio using Bioconductor (http://www.bioconductor.org). All values of these canonical pathways were significant.
Table 1: Canonical pathways associated with the DEGs from 60 dpc.