Canonical Pathwaysanuity Canonical Pathways pp-valueb
Inhibition of Angiogenesis by TSP1 (tumor suppressor region 1) 1.73E00
Mechanisms of Viral Exit from Host Cells 1.25E00
PKCθ (protein kinase C theta ) Signaling in T Lymphocytes 8.05E-01
Caveolar-mediated Endocytosis Signaling 6.7E-01
FcγRIIB (Fc receptor or CD32) Signaling in B Lymphocytes 6.03E-01
Phospholipase C Signaling 4.97E-01
RhoA (RhoA kinase) Signaling 4.79E-01
Complement System 4.79E-01
NRF2(nuclear factor erythroid 2) mediated Oxidative Stress Response 4.36E-01
Lipid Antigen Presentation by CD1 4.28E-01
Role of JAK2 (Janus Kinase 2) in Hormone-like Cytokine Signaling 4.18E-01
Coagulation System 3.63E-01
Crosstalk between Dendritic Cells and Natural Killer Cells 3.55E-01
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells 3.34E-01
Retinoic acid Mediated Apoptosis Signaling 3.25E-01
Endoplasmic Reticulum Stress Pathway 2.99E-01
Role of JAK1 (Janus Kinase 1), JAK2 and TYK2 (tyrosine kinase 2) in Interferon Signaling 2.81E-01
a Functional annotation analysis of the differentially expressed genes (DEGs) with the IPA (Ingenuity Pathway Analysis, http://www.ingenuity.com) tools. The IPA tool defines the most significant biological functions through association with the largest number of DEGs correlated to these functions. Canonical pathways are known classic routes and well-established of biological functions evidenced by validated genes.
bP value determined from the average log2 ratio using Bioconductor (http://www.bioconductor.org). All values of these canonical pathways were significant.
Table 2: Canonical pathways associated with the DEGs from 120 dpc.