NP type Para- meter Zeta Potential (mV) Diameter ± SD (nm) PI EE (%) Drug concentration, mg/ml PLGA -14.8 ± 3.9. 527 ± 97 0.4 - - PLGA-RIF -20.7 ± 0.7 464 ± 129 0.2 31.8 5,3 NLC-RIF -26.1 ± 0.7 251 ± 12 0.1 92 14.6 NLC-OXA -32.0 ± 0.5 193 ± 8 0.1 93 7.4 NLC -35.9 ± 0.6 266 ± 14 0.1 - -

Table 1: Summary of PLGA NPs and NLC properties. All the parameters are represented by their average value obtained from at least three multiple measurements. PI- polydispersity index.