| Disease or condition |
Clinical characteristics |
| Recurrent aphthous stomatitis |
Appearance of ulcers (aphthae) in oral mucosa with yellowish base, surrounded by an erythematous halo and regular margins and that disappear without treatment. Acute course |
| Behçet’s disease |
Appearance of aphthae in the oral mucosa with genital and ocular ulcers |
| Eerythema multiforme |
Target-shaped skin lesions, oral erosions, involvement of lips in the form of erosions and crusts |
| Erosive lichen planus |
Appearance of Wickham striae and erosive lesions |
| Oral candidiasis |
Whitish lesions that detach on scraping and atrophic erythematous areas |
| Acute herpetic gingivostomatitis |
Prodromic symptoms followed by the onset of small yellowish vesicles that rapidly rupture, giving rise to ulcers with an erythematous halo. It affects free and attached g ingiva. |
| Impetigo |
Bacterial infection with appearance of skin ulcers covered by a honey-colored crust. It affects face, arms and legs. It is more frequent in children. |
| Disease by linear IgA deposit |
Symmetric blisters and pruritic lesions, target-shaped lesions |
| Mucosal pemphigoid or cicatricial pemphigoid |
Possible manifestation of an underlying malignant disease: oral lesions do not precede skin lesions, and blisters are smaller with a shorter duration than in PV. They heal rapidly without scarring |
| Bullous pemphigus |
Vesicles or tension blisters with clear content that develop on normal or erythematous skin; intense pruritus, symmetric lesions that appear on flexion areas, root of extremities, thighs, and abdomen; rare on mucosae. |
| Herpetiform dermatitis |
1-3 cm erythemas that infiltrate palate and buccal mucosa; aphthae on labial mucosa. They appear months or years after the appearance of lesions on skin |
| Epidermolysis bullosa |
Development of blisters with minimal pressure, ring-shaped atrophic scars on the inner surface of limbs and articulations |
| Paraneoplastic pemphigus |
Autoimmune syndrome associated with lymphoproliferative neoplasm of B cells |
| Erythematous pemphigus |
There are usually no oral lesions |
| Pemphigus foliaceus |
There are usually no oral lesions |
| Chronic benign pemphigus familiaris |
There are usually no oral lesions |
| Disseminated lupus erythematosus |
Systemic signs (fever, asthenia) normally accompanied by petechiae, edemas and dry mouth |
| Crohn’s disease and hemorrhagic rectal colitis |
Mucocutaneous signs accompanied by abdominal pain, aphthae in oral mucosa, asthenia, weight loss, and anorexia |
| Folic acid or vitamin B12 deficiency |
Oral pain, erythematous tongue, asthenia and anemia, paresthesias in limbs, and physical problems |
| Hypochromic iron deficiency |
Pallor, fatigue, cephalalgias, vertigo, buzzing in the ears, irritability, insomnia, concentration problems, sensitivity to cold, anorexia and nausea |
| Enteropathic acrodermatitis |
Loss of taste and smell, sight problems, intense diarrhea, alopecia, and hypertension |
