Figure 2: Clinical findgins of two sporadic NF1 patients. Sporadic patient 1 (A and B) present the most severe condition in this study, with numerous tumors from 1cm to 10cm in diameter covering 70 percentages of the body surface.Sporadic patient 2 only show a few café-au-lait spots and skin-colored small nodules (E), with striking lesions including puritic, red papules on the face (C) and depigmented firm nodules on both hands (D).