Compound Cell Number TC50 (μM) Mem Tox TC50 (μM) MTT TC50 (μM) ATP TC50 (μM) Predicted Ctox(μM)
J-147 293 >300 228 210 90
Rotenone 0.04 0.93 0.07 0.05 Control (~ 0.03)
Camptothecin 0.6 >300 0.5 0.3 Control (~0.1)
TC50=concentration that produced a half-maximal response.
Cell Number (or mass). (n=7 replicates).
MemTox=Membrane toxicity measured using GST leakage. (n=3 replicates).
MTT=3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide. (n=7 replicates).
ATP=adenosine triphosphate content. (n=7 replicates).
Table 1: Comparison of J-147 with Control compounds on Cell Toxicity.