| Patient |
Age (yrs); Sex |
Clinical Features |
Cancer |
VGKC Monitoring (days) |
VGKC Titer (nmol/L) Normal <0.02nmol/L |
CSF Protein Results (mg/dL) Normal 15-60mg/dL |
Treatment |
AEDS |
MRI |
Hypothalamic Involvement on MRI |
| 1 |
93F |
Altered mental status |
No |
Initial |
0.13 |
57 |
None |
None |
Global atrophy, laminar necrosis left parietal lobe |
No |
| 2 |
60M |
Autonomic seizure |
No |
Initial |
1.58 |
NA |
IVIG |
LCM, LTG |
Bilateral mesial temporal lobe hyperintensity |
Yes |
| |
|
|
|
54 |
4.22 |
|
PLEX |
|
|
|
| |
|
|
|
161 |
15.8 |
|
|
|
|
|
| |
|
|
|
273 |
1.94 |
|
|
|
|
|
| 3 |
53F |
Altered mental status, depression |
No |
Initial |
0.76 |
69 |
IVMP x5 days, IVIG x5 days |
LEV, LCM |
Bilateral hyperintensity in the restiform bodies |
No |
| 4 |
55M |
Altered mental status |
No |
Initial |
3.89 |
101 |
IVMP x5 days, PLEX x5 days |
ZON, LEV, LCM |
Right unilateral mesial temporal lobe hyperintensity |
No |
| 5 |
37F |
Complex partial seizure |
No |
Initial |
2.8 |
47 |
IVIG x3 days, IVMP x3 days, PLEX x5 days |
VPA, LEV, PHT |
Bilateral basal ganglia/hippocampus hyperintensity |
Yes |
| |
|
|
|
408 |
0.77 |
|
|
|
|
|
| 6 |
85M |
Altered mental status, seizure |
No |
Initial |
0.692 |
48 |
IVMP x5 days, PLEX x3 days/week for 2 weeks |
VPA, LEV, TPM |
Right unilateral mesial temporal lobe hyperintensity |
Yes |
Abbreviations: M=male, F=female, VGKC=voltage gated potassium channel antibody, CSF=cerebrospinal fluid, IVMP=1 gram of intravenous methylprednisolone,
IVIG=0.4g/kg/d of intravenous immunoglobulin, PLEX=plasma exchange |
