Figure 1: Suramin inhibits PTP1B with an IC50 of 16.34 μM; PTP1B assays were run in triplicate with either buffer or suramin (0.1mM-1nM). Significantly different (***p<0.01) from baseline enzyme activity levels measured by phosphate product produced over 30 minutes. IC50 value is calculated inhibitory concentration required for 50% enzyme activity inhibition compared to baseline control. Paired-t-test was used for statistical analysis (Graph Pad Inc.).