Figure 1: Percent of leg usage during movement. Leg usage during movement in the cage was scored 4 days after the sciatic nerve neuropathy surgery. For each animal, 10 sampling segments were performed, with 30 seconds in each segment. Normal movement with alternating usage of both legs was scored as normal, and skipping on one leg while keeping the other leg held-up in the air was scored as usage avoidance of the held-up leg. The 10 scores were averaged for each leg to obtain percent of leg usage. For each group of animals, the scores for leg of ipsilateral side and contralateral side were averaged separately, and data are presented as mean ± SEM. Data of sham operated animals (n=9) are plotted on the left, and data of SNN animals (n=9) are plotted on the right. Filled bar, ‘Ipsi’ (ipsilateral side of either sham or SNN surgery); open bar, ‘Contra’ (contralateral side of either sham or SNN surgery). *, significantly different from contralateral side (p<0.05, unpaired t test with Welch’s correction). |