Dosing in Non-Valvular AF
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Dabigatran (high dose)
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150 mg twice daily
Contraindicated if CrCl < 30 mL/hr
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Dabigatran (low dose)
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110 mg twice daily
Contraindicated if CrCl < 30 mL/hr
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Rivaroxaban
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20 mg daily if CrCl ≥50 mL/hr
15 mg daily if CrCl 30 – 50 mL/hr
Contraindicated if CrCl < 30 mL/hr
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Apixaban
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5 mg twice daily
2.5 mg twice daily if at least 2 of the 3:
- Age ≥80 years
- Weight < 60 kg
- Creatinine
Contraindicated if CrCl < 25 mL/hr
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Edoxaban (high dose)
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60 mg daily
30 mg daily if at least 1 of the 3:
CrCl 30 – 50 mL/hr
Weight < 60 kg
Concomitant P-glycoprotein inhibitor or dronedarone use
Contraindicated if CrCl < 30 mL/hr
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Edoxaban (low dose)
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30 mg daily
15 mg daily if at least 1 of the 3:
CrCl 30- 50 mL/hr
Weight < 60 kg
Concomitant P-glycoprotein inhibitor or dronedarone use
Contraindicated if CrCl < 30 mL/hr
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