HLA DRB1 alleles value to disability OCB value to disability HLA DRB1 alleles and OCB interaction value to disability Allele p value p value p value *01 0.2 0.7 0.38 *03 0.19 0.11 0.69 *04 0.087 0.008 0.92 *07 0.93 0.0001 0.049 *08 0.062 0.018 0.87 *11 0.14 0.005 0.41 *12 0.11 0.14 0.51 *13 0.18 0.005 0.83 *14 0.32 0.7 0.13 *15 0.4 0.003 0.73 *16 0.23 0.024 0.3

Table 2: Statistical significance of the HLA DRB1 alleles, oligoclonal bands, and their interactions to disability of multiple sclerosis patients (EDSS score), (two-factorial analysis; EDSS - Expanded Disability Status Scale, OCB – oligoclonal bands.